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Home Antibody All anti-TARDBP antibodies

Anti-TARDBP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301509
  • Rabbit Polyclonal Antibody against TARDBP
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402137) , 20ug
100ul 325 In Stock
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WB(2)
IF(1)
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Also for TARDBP (NM_007375)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide to a C-terminal region [within residues 350-414] of the human TARDBP protein. [Swiss-Prot# Q13148]
Clone Name IsotypeIgG
Species Reactivityhuman, primate, mouse, chicken, Xenopus, Zebrafish ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5-2 ug/ml
BufferTris-glycine, 150mM NaCl and 0.05% sodium azide
Purification Immunogen affinity purified

Reference Data

Target NameHomo sapiens TAR DNA binding protein (TARDBP)
Alternative NameALS10; TDP-43
Database LinkNP_031401
FunctionThe HIV1 virus gives rise to acquired immunodeficiency syndrome (AIDS). HIV1 contains an RNA genome which produces chromosomally integrated DNA during cellular replication. Gene activation of HIV1 by the transactivator Tat requires an RNA regulatory element TAR which is located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to the chromosomally integrated TAR DNA, preventing HIV1 expression. Additionally, this protein regulates alternative splicing of the CTFR gene, a similar pseudogene on chromosoome 20. TARDBP has also been recently been shown to abnormally accumulate in the post-mortem brain tissue of individuals diagnosed with ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This long-awaited conncection between these two diseases provides an explanation for the observed clinical overlap.
Related Pathway

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WB Image
Detection of TARDBP in HeLa WCE
WB Image
Western Blot: TARDBP Antibody - Cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY TARDBP cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TARDBP.
IF Image
Immunocytochemistry/Immunofluorescence: TARDBP antibody was tested in MCF-7 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

 

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