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Home Antibody All anti-CUGBP1 antibodies

Anti-CUGBP1 Antibody 3B1

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301501
  • Mouse Monoclonal Antibody against CUG-BP1 (3B1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401964) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IF(1)
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Also for CUGBP1 (NM_006560)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenCUG-BP1 human nuclear RNA binding protein.
Clone Name3B1 IsotypeIgG1 kappa
Species Reactivityhuman, mouse, rat, bovine, porcine, rabbit Concentration8.3 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:500
BufferAscitic fluid and 0.1% sodium azide
Purification Ascites

Reference Data

Target NameHomo sapiens CUGBP, Elav-like family member 1 (CELF1), transcript variant 1
Alternative NameBRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP; hNab50; NAB50; NAPOR
Database LinkNP_006551
Entrez Gene 10658 Human
Entrez Gene 13046 Mouse
Entrez Gene 362160 Rat
FunctionMyotonic dystrophy (MD) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3-untranslated region of the myotonin protein kinase (Mt-PK) gene. A (CUG) n oligonucleotides triplet repeat pre-mRNA/mRNA binding protein may play an important role in DM pathogenesis. HeLa cell protein, CUG-BP1, has been purified based upon its ability to bind specifically to (CUG) 8 oligonucleotides in vitro. CUG-BP1 is the major (CUG) 8 - binding activity in normal cells. CUG-BP1 has been identified as isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. The CUG-BP/hNab50 protein is localized predominantly in the nucleus and is associated with polyadenylated RNAs in vivo. In vitro RNA-binding/photocrosslinking studies demonstrate that CUG-BP/hNab50 binds to RNAs containing the Mt-PK 3-UTR. The (CUG) n repeat region in Mt-PK mRNA is a binding site for CUG-BP/hNab50 in vivo, and triplet repeat expansion leads to sequestration of this hnRNP on mutant Mt-PK transcripts.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Detection of CUG-BP1 in several cell lysates
IF Image
Detection of the subcellular distribution of CUGBP1 (nuclear, non-nucleolar) in normal and DM1 (dystrophia myotonica) myoblasts

 

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