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Anti-RAD50 Antibody zinc hook domain


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  • Rabbit Polyclonal Antibody against RAD50 (zinc hook domain)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401747) , 20ug Explanation
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OriGene Data

ImmunogenHuman Rad50 zinc hook region (amino acids 628-787) expressed in E. coli.
Clone Namezinc hook domain IsotypeIgG
Species Reactivityhuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1: 1000-1: 10000

Reference Data

Target NameHomo sapiens RAD50 homolog (S. cerevisiae) (RAD50)
Alternative NamehRad50; NBSLD; RAD502
Database LinkNP_005723
Entrez Gene 10111 Human
FunctionRad50, a 153kDa protein, is associated with Mre11 and Nbs1 (Nibrin or p95) to form a multiprotein complex involved in the double strand break repair process. Rad50 is a member of the family of structural maintenance of chromosome (SMC) proteins. Members of this family share similar structures consisting of globular N- and C-termini separated by a coiled-coil domain. At the base of the coiled-coil region is a zinc binding motif, the zinc hook. The zinc hook mediates Rad50 dimerization through the linkage of two Rad50 coiled-coil tails.
Related PathwayDruggable Genome Homologous recombinationNon-homologous end-joining

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WB Image
Detection of Rad50. Lane 1: 25 ng purified hMre11-hRad50 complex. Lane 2: 25 ug crude HeLa extract


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