Home Antibody All anti-SCARB1 antibodies
Also for SCARB1 (NM_005505)
|A C-terminal peptide containing residues from mouse Scavenger Receptor-BI (within residues 450-509).|
|human, mouse, rat, mink, hamster
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1: 1000-1:5000
|Tris-citrate/phosphate [pH 7-8] buffer. and 0.1% Sodium Azide|
|Homo sapiens scavenger receptor class B, member 1 (SCARB1), transcript variant 1|
|CD36L1; CLA-1; CLA1; HDLQTL6; SR-BI; SRB1|
Entrez Gene 949 Human
Entrez Gene 20778 Mouse
Entrez Gene 25073 Rat
|High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. |
|TransmembraneDruggable Genome |
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Detection of SR-BI in 25 ug of mouse liver lysate, using anti-SRBI at a 1:1,000 dilution, shows distinct band at 82 kDa.
Western Blot: SR-BI Antibody [NB400-104] - Detection of SR-BI in rat H4IIE total cell lysates and plasma membrane proteins.
Immunohistochemistry: Immunolocalization of SR-BI in adult mink testis using SR-BI Antibody. SR-BI labeling is visible at the surface and along the outline of the large vacuole.
Immunocytochemistry/Immunofluorescence: SRB1 antibody was tested at 1:50 in HeLa cells with FITC (green). Nuclei and actin were counterstained with Dapi (blue) and Phalloidin (red).