Home Antibody All anti-ATG5 antibodies
Also for ATG5 (NM_004849)
|A synthetic peptide made to an N-terminal region (within residues 1-50) of the human ATG5 protein. [Swiss-Prot# Q9H1Y0]|
|human, mouse, rat, cow, porcine, primate, Xenopus, Zebrafish
|WB, IHC, IF
|PBS plus 30% glycerol and 0.1% sodium azide|
|peptide affinity purified
|Homo sapiens autophagy related 5 (ATG5), transcript variant 1|
|APG5; APG5-LIKE; APG5L; ASP; hAPG5|
Entrez Gene 9474 Human
Entrez Gene 11793 Mouse
Entrez Gene 365601 Rat
|Autophagy is an important mechanism for nonselective intracellular breakdown whereby cytosol and organelles are encapsulated in vesicles, which are then engulfed and digested by lytic vacuoles/lysosomes. ATG5 is required for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Conjugation to ATG12 is essential for autophagy, but is not required for association with isolation membrane. ATG5 also plays an important role in the apoptotic process. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. |
|Druggable Genome Regulation of autophagyRIG-I-like receptor signaling pathway|
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Detection of ATG5 in mouse wildtype ES cell lysate (Lane 1). Lane 2 is a mouse ATG5 KO ES cell lysate (negative control).
Staining of hepatocytes at 2.5ug/ml. Human liver hepatocytes 40X magnification.
Immunohistochemistry: ATG5 Antibody - Analysis of ATG5 in mouse intestine using DAB with hematoxylin counterstain.
Immunofluorescent staining of SY5Y cells at 1:250. Incubated overnight at 4 degrees.