Home Antibody All anti-POU5F1 antibodies
Also for POU5F1 (NM_002701)
|A synthetic peptide made to an internal portion of the human OCT4 protein sequence (between residues 100-200).|
|Tris-glycine, 150mM NaCl and 0.05% sodium azide|
|Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1|
|Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4|
Entrez Gene 5460 Human
Entrez Gene 714760 Monkey
|Stem cells are crucial ingredients in the progressive restriction of cellular developmental capacity during mammalian embryogenesis. Until recently, only embryonic stem cells (ESC) had been shown to exhibit the potential to differentiate into cells of the all three germ layers. However, adult stem cells (ASC) can regain pluripotency (potential to differentiate into various lineages) if transferred from one stem-cell microenvironment into another. The transcription factor OCT4, expressed in ESCs and germ cells, is strongly implicated in the process of maintaining as well as regaining stem-cell pluripotency and functions as a key regulator of mammalian germline development. |
|Stem cell - PluripotencyAdult stem cellsCancer stem cellsEmbryonic stem cellsInduced pluripotent stem cellsTranscription Factors |
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Detection of OCT4 in mouse brain lysate
Flow Cytometry: Staining of NTERA-2 cells using OCT4 antibody at a 1:50 dilution detected using Dylight-488 conjugated goat anti-rabbit secondary antibody.