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Anti-ARNT Antibody H1beta234


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA301443 Mouse Monoclonal Antibody against HIF-1 Beta (H1beta234) 100ul $325 3-7 Days
LC400636 ARNT HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenFusion protein containing amino acids 496-789 of human HIF-1 beta.
Clone NameH1beta234 IsotypeIgG1 kappa
Species Reactivityhuman, bovine, sheep, mouse, rat, ferret Concentration1.4 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500
BufferPBS and 0.05% sodium azide
Purification protein G purified

Reference Data

Target NameHomo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 1
Alternative NamebHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO
Database LinkNP_001659
Entrez Gene 405 Human
Entrez Gene 11863 Mouse
Entrez Gene 25242 Rat
FunctionHypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products.
Related PathwayTranscription FactorsDruggable Genome Pathways in cancerRenal cell carcinoma

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western Blot: HIF-1 beta Antibody (H1beta234)TA301443 - Analysis of HIF-1 beta in HeLa nuclear extract.

IHC Image
Immunohistochemical staining of human glioblastoma multi-forme utilizing anti-HIF-1 Beta


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