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Home Antibody All anti-ARNT antibodies

Anti-ARNT Antibody H1beta234

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301443
  • Mouse Monoclonal Antibody against HIF-1 Beta (H1beta234)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400636) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for ARNT (NM_001668)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFusion protein containing amino acids 496-789 of human HIF-1 beta.
Clone NameH1beta234 IsotypeIgG1 kappa
Species Reactivityhuman, bovine, sheep, mouse, rat, ferret Concentration1.4 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500
BufferPBS and 0.05% sodium azide
Purification protein G purified

Reference Data

Target NameHomo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 1
Alternative NamebHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO
Database LinkNP_001659
FunctionHypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products.
Related Pathway

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WB Image
Western Blot: HIF-1 beta Antibody (H1beta234)TA301443 - Analysis of HIF-1 beta in HeLa nuclear extract.
IHC Image
Immunohistochemical staining of human glioblastoma multi-forme utilizing anti-HIF-1 Beta

 

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