Home Antibody All anti-ARNT antibodies
Also for ARNT (NM_001668)
|Fusion protein to human HIF-1 beta. Containing a.a. 496-789.|
|human, bovine, sheep, mouse, rat, ferret
||Lot dependent; please refer to CoA along with shipment
|0.02% sodium azide|
|Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 1|
|bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO|
Entrez Gene 405 Human
Entrez Gene 11863 Mouse
Entrez Gene 25242 Rat
|Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. (1,5,6) |
|Transcription FactorsDruggable Genome Pathways in cancerRenal cell carcinoma|
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Western Blot: HIF-1 beta Antibody TA301442 - WB analysis of HIF-1 beta in MCF7 whole cell lysate.