Homo sapiens endothelial PAS domain protein 1 (EPAS1)
Synonyms:
bHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2
Immunogen
Human HIF-2 alpha amino acids 535-631.
Buffer
PBS and 0.1% sodium azide
Clone Name
ep190b
Isotype
IgG1
Species Reactivity
human, rat
Concentration
1.6 mg/ml
Purification
protein G purified
Guaranteed Application *
WB, IHC
Suggested Dilutions
WB (1:500), IHC (1:150-1:300)
Background
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-2 alpha is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF-1 alpha functions primarily in extravascular tissues. HIF-2 alpha is also a potent activator of the tie-2 gene, which is known to be selectively expressed in endothelial cells.
Related Pathway
Adipogenesis
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