Home Antibody All anti-CA9 antibodies
|A synthetic peptide derived from a C-terminal sequence of the human CA IX.|
|WB, IHC, IF
||WB: 1: 1000, IHC: 1: 1000, IF: 1: 1000
|Immunogen affinity purified (Protein A or G Sepharose)
|Homo sapiens carbonic anhydrase IX (CA9)|
|Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. Because of its functionality, it has become an important diagnostic marker for various cancers, most notably renal cell carcinoma (RCC). There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and the location of the expressed protein within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia. |
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Western Blot: Carbonic Anhydrase IX Antibody - Analysis of CAIX on rat renal cortex using TA301431
Immunohistochemistry-Frozen: Carbonic Anhydrase IX Antibody - Analysis of human colon carcinoma, xenografted in mice. Image courtesy of an anonymous product review.
Immunocytochemistry/Immunofluorescence: Immunofluorescence of human RCC tumor cryosections using TA301431 (Panel A). Panel B shows staining with normal rabbit serum.