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Home Antibody All anti-BIRC5 antibodies

Anti-BIRC5 Antibody 60.11

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301428
  • Mouse Monoclonal Antibody against Survivin (60.11) - Astrocyte Marker
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400469) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for BIRC5 (NM_001168)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant human survivin, full-length
Clone Name60.11 IsotypeIgG2a kappa
Species Reactivityhuman, mouse, rat Concentration0.9 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 2 ug/ml
Buffer0.1% sodium azide
Purification protein G purified

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 1
Alternative NameAPI4; EPR-1
Database LinkNP_001159
FunctionRegulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a C-terminal RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury.
Related Pathway
Apoptosis
Cell cycle

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WB Image
Detection of Survivin in HeLa whole cell extract
IHC Image
Staing of ovary, cancer

 

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