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Home Antibody All anti-CDKN2A antibodies

Anti-CDKN2A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301407
  • Rabbit Polyclonal Antibody against p14ARF
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400022) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for CDKN2A (NM_000077)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide made to a portion of human p14ARF (between residues 100-173). [Swiss-Prot# Q8N726]
Clone Name IsotypeIgG
Species Reactivityhuman Concentration2.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 2 ug/ml
BufferTris-glycine, 150mM NaCl and 0.05% sodium azide
Purification Affinity purified

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 2A (CDKN2A), transcript variant 1
Alternative NameARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4;
Database LinkNP_000068
Entrez Gene 1029 Human
FunctionThe INK4a-ARF locus is comprised of two tumor suppressors, p16INK4a and p14ARF. These two proteins are encoded through differential splicing of alternative first exons. The p16INK4a (exon 1 alpha) protein inhibits the cyclin D-dependent kinases (CDK) that control the phosphorylation of the Rb protein and cell proliferation. The p14ARF gene product complexes with the MDM2 protein within the nucleus, thus modulating the activity of the p53 protein. P14ARF is a potent tumor suppressor in the presence of wild-type p53, while mutant p53 substantially reduces growth inhibition by p14ARF.
Related Pathway
Apoptosis
Cell cycle
Senescence and Autophagy

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Detection of p14ARF in HeLa whole cell extract

 

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