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Anti-C1QC Antibody EPR2983
Also for C1QC (NM_172369)
|A synthetic peptide corresponding to residues in human C1q (subunit C) was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1: 1000~5000; IHC: 1: 100~250; ICC: 1: 100; FC: 1:50; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens complement component 1, q subcomponent, C chain (C1QC), transcript variant 2|
Entrez Gene 714 Human
|The complement component C1 is a protein complex that consists of six subunits of C1q. Each C1q subunit of the complex is known to bind to immune complexes, which often are deposited in basement membrane. C1q consists of three different species of chains called A, B and C. It is a versatile recognition protein that triggers activation of the classical pathway of complement, where the first step involves the binding of the globular domain of Clq to the Fc regions of aggregated IgG or IgM. The C1q globular domain is a heterotrimer of the C-terminal halves of one A, one B, and one C chain, held together mainly by non-polar interactions, with a Ca2+ ion bound at the top. A modular organization has been suggested of the globular domain, consistent with the view that A, B, and C chains are functionally autonomous modules and have distinct and differential ligand-binding properties (1-3). |
|Secreted Protein Complement and coagulation cascadesPrion diseasesSystemic lupus erythematosus|
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Western blot - C1QG antibody [EPR2983]; All lanes : Anti-C1QG antibody [EPR2983] at 1/5000 dilution.Lane 1 : human plasma lysate.Lane 2 : human spleen lysate.Lane 3 : fetal marrow lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.Observed band size : 26 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - C1QG antibody [EPR2983]; Immunohistochemical analysis of paraffin-embedded human spleen tissue using 1/100-1/250 TA301374.