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Anti-RAD17 PHOSPHO Antibody EPR3145


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against RAD17 (Clone EPR3145) (Phospho-specific)
100ul 325 3-7 Days
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OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues in human Rad17 was used as an immunogen. The antibody only detects Rad17 phosphoryated on Serine 656.
Clone NameEPR3145 IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:5,000~10,000; IHC: 1: 100~250; ICC: 1: 100~250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens RAD17 homolog (S. pombe) (RAD17), transcript variant 7
Alternative NameCCYC; HRAD17; R24L; RAD17SP; RAD24
Database LinkNP_579922
FunctionCheckpoint Rad proteins function early in the DNA damage signaling cascade to arrest cell cycle progression in response to DNA damage (1). There is a direct regulatory linkage between Rad17 and the checkpoint kinases, ATM and ATR (2). Rad17 has been reported to be a phosphorylation substrate of ATR and is critical for ATR-mediated checkpoint signaling and cell survival. Phosphorylation of Rad17 by ATR is important for genomic stability and restraint of S phase but is not essential for cell survival (3).
Related Pathway

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WB Image
Western blot - Rad17 (phospho S656) antibody [EPR3145]; All lanes : Anti-Rad17 (phospho S656) antibody [EPR3145] at 1/10000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate treated with Calyculin A.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 77 kDa.Observed band size : 80 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Rad17 (phospho S656) antibody [EPR3145]; TA301364, at 1/100-1/250 dilution, staining Rad17 in human breast carcinoma by immunohistochemistry using paraffin-embedded tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - Rad17 (phospho S656) antibody [EPR3145]; TA301364, at 1/100-1/250 dilution, staining Rad17 in HeLa cells by immunofluorescence.


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