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Anti-ADIPOQ Antibody EPR3217
Also for ADIPOQ (NM_004797)
|A synthetic peptide corresponding to residues on human Adiponectin was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:2,000~5,000; ICC: 1: 100~250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), transcript variant 2|
|ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28|
|Adiponectin is a multimeric adipocyte-specific secretory protein that regulates energy homeostasis, lipid metabolism, and insulin sensitivity with direct anti-diabetic, anti-atherogenic and anti-inflammatory properties. Adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells and is an important negative regulator in hematopoiesis and immune systems (1, 2). Adiponectin is reported to possibly function as an endogenous factor involved in lipid catabolism and storage or whole body metabolism (3). It is decreased in obesity and has been demonstrated to inhibit tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules. Adiponectin modulates the inflammatory response of endothelial cells, possibly through cross talk between cAMP-PKA and NF-kappaB signaling pathways (4). |
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Western blot - Adiponectin antibody [EPR3217]; All lanes : Anti-Adiponectin antibody [EPR3217] at 1/5000 dilution.Lane 1 : Fetal fat lysate.Lane 2 : Human plasma lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.Observed band size : 30 kDa .Additional bands at : 56 kDa (possible dimer).