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Anti-CD5 Antibody EPR2953
|A synthetic peptide corresponding to residues in human CD5 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||ICC/IF: 1:100; WB: 1:1000 - 1:10000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens CD5 molecule (CD5)|
|CD5 (Lymphocyte antigen T1/Leu-1) is a transmembrane glycoprotein which has been implicated as a single-pass type I receptor in the regulation of T-cell proliferation (1). CD5 is part of the scavenger receptor cysteine-rich (SRCR) family group B and it is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is also expressed by T cell leukemia, lymphomas, activated T cells, and occasionally a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5 positive while the follicle center cell lymphomas are CD5 negative. A ligand for CD72/LYB-2, CD5 has been linked to negative regulation of T cell and B cell receptors signaling (2). |
Hematopoietic cell lineage
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Western blot - Anti-CD5 antibody [EPR2953]; Anti-CD5 antibody [EPR2953] at 1/1000 dilution + PMBC treated with TPA cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 54 kDa.