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Home Antibody All anti-CD5 antibodies

Anti-CD5 Antibody EPR2953

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA301350
  • Rabbit Monoclonal Antibody against CD5 (Clone EPR2953)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415443) , 20ug Explanation
100ul 325 In Stock
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WB(1)
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Also for CD5 (NM_014207)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD5 was used as an immunogen.
Clone NameEPR2953 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsICC/IF: 1:100; WB: 1:1000 - 1:10000
BufferpH: 7.40Preservative: 0.01% Sodium azideConstituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens CD5 molecule (CD5)
Alternative NameLEU1; T1
Database LinkNP_055022
Entrez Gene 921 Human
FunctionCD5 (Lymphocyte antigen T1/Leu-1) is a transmembrane glycoprotein which has been implicated as a single-pass type I receptor in the regulation of T-cell proliferation (1). CD5 is part of the scavenger receptor cysteine-rich (SRCR) family group B and it is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is also expressed by T cell leukemia, lymphomas, activated T cells, and occasionally a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5 positive while the follicle center cell lymphomas are CD5 negative. A ligand for CD72/LYB-2, CD5 has been linked to negative regulation of T cell and B cell receptors signaling (2).
Related PathwayTransmembraneDruggable Genome Hematopoietic cell lineage

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CD5 antibody [EPR2953]; Anti-CD5 antibody [EPR2953] at 1/1000 dilution + PMBC treated with TPA cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 54 kDa.

 

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