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Home Antibody All anti-CUL4B antibodies

Anti-CUL4B Antibody EPR3200

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301340
  • Rabbit Monoclonal Antibody against CUL4B (Clone EPR3200)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418558) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for CUL4B (NM_003588)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CUL4A/B was used as an immunogen.
Clone NameEPR3200 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2,000~10,000; IHC: 1: 100~250; FC: 1:60
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens cullin 4B (CUL4B), transcript variant 1
Alternative NameCUL-4B; MRXHF2; MRXS15; MRXSC; SFM2
Database LinkNP_003579
FunctionCullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various physiological processes, including regulating replication and transcription (1-2). Two cullin 4 (CUL4) proteins, CUL4A and CUL4B, have been identified. CUL4A and CUL4B are two closely related proteins, coded by two different genes. The amino acid sequences of CUL4A and CUL4B show 80% similarity, differing by the unique and extended N-terminus of CUL4B. CUL4B is reported to be found in the nucleus as well as the cytoplasm during differentiation, while CUL4A has been reported to be present predominantly in the cytoplasm. CUL4B is suggested to have a more specific role than CUL4A due to the presence of functional nuclear localization signal sequence in the N-terminus. CUL4A is noted as essential for embryonic development (3).
Related Pathway

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WB Image
Western blot - Cullin 4A/B antibody [EPR3200]; All lanes : Anti-Cullin 4A/B antibody [EPR3200] at 1/5000 dilution.Lane 1 : Fetal uterus lysate.Lane 2 : Hela lysate.Lane 3 : A375 lysate.Lane 4 : Fetal testis lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 102 kDa.Observed band size : 88,102 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cullin 4A/B antibody [EPR3200]; TA301340 at 1/100 dilution staining Cullin 4B in human brain tissue, using a HRP/AP polymerized secondary antibody.

 

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