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Anti-CRADD Antibody EPR1639
Also for CRADD (NM_003805)
|A synthetic peptide corresponding to residues in human RAIDD was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:5000; IP: 1:40; ICC: 1:100 - 1:250; FC: 1:30
|Does not react with Mouse. Is unsuitable for IHC-P.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for IHC-P.
|Homo sapiens CASP2 and RIPK1 domain containing adaptor with death domain (CRADD)|
|RAIDD (RIP-associated ICH-1/CED-3-homologous protein with a death domain), is a dual-domain adaptor protein that is constitutively expressed in many tissues (1, 2). RAIDD has an N-terminal caspase recruitment domain (CARD) that interacts with the CARD of caspase-2, and a C-terminal death domain (DD) that interacts with the DD in PIDD (p53-induced protein with a death domain) (3). RAIDD has been shown to mediate the recruitment of CASPASE-2 to tumour necrosis factor receptor-1 (TNF-R1) signalling complex through RIP kinase. Apart from its established role in apoptosis, RAIDD may have an additional function in cell differentiation, supported by its expression in developing organs derived from the ectoderm, like heart and kidney. In developing heart and kidney RAIDD expression patterns are reported to overlap with known zones of cell death suggesting RAIDD may be involved in apoptosis-mediated remodeling (1). |
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Western blot - RAIDD antibody [EPR1639]; All lanes : Anti-RAIDD antibody [EPR1639] at 1/5000 dilution.Lane 1 : Raji cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : K562 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 23 kDa.Observed band size : 23 kDa.