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Home Antibody All anti-ESR1 antibodies

Anti-ESR1 PHOSPHO Antibody EPR2163Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301320
  • Rabbit Monoclonal Antibody against ESR1 (Clone EPR2163Y) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
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Also for ESR1 (NM_000125)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding Serine 167 of human ER alpha was used as an immunogen. The antibody only detects ER alpha phosphorylated at Serine 167.
Clone NameEPR2163Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:1000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens estrogen receptor 1 (ESR1), transcript variant 1
Alternative NameER; Era; ESR; ESRA; ESTRR; NR3A1
Database LinkNP_000116
Entrez Gene 2099 Human
FunctionEstrogen receptor alpha (ER alpha) is a nuclear protein and member of the steroid hormone receptor family. ER alpha possesses both DNA binding and ligand binding domains, and exerts a significant role in activating the transcription of certain genes (1). Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha (2). Phosphorylation of ER alpha at Serine 118 and ER alpha at Serine 167 affects survival in estrogen receptor (ER)-positive breast cancer and could be helpful in distinguishing patients who are likely to benefit from endocrine therapy alone from those who are not (3).
Related PathwayNuclear Hormone ReceptorTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Estrogen Receptor alpha (phospho S167) antibody [EPR2163Y]; All lanes : Anti-Estrogen Receptor alpha (phospho S167) antibody [EPR2163Y] at 1/1000 dilution.Lane 1 : MCF-7 cell lysate, untreated.Lane 2 : MCF-7 cell lysate, treated with Lambda Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.HRP-conjugated goat anti-rabbit at 1/2000 dilution.Predicted band size : 66 kDa.Observed band size : 66 kDa.

 

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