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Anti-ESR1 PHOSPHO Antibody EPR2163Y
Also for ESR1 (NM_000125)
|A phospho-specific peptide corresponding to residues surrounding Serine 167 of human ER alpha was used as an immunogen. The antibody only detects ER alpha phosphorylated at Serine 167.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500 - 1:1000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens estrogen receptor 1 (ESR1), transcript variant 1|
|ER; Era; ESR; ESRA; ESTRR; NR3A1|
|Estrogen receptor alpha (ER alpha) is a nuclear protein and member of the steroid hormone receptor family. ER alpha possesses both DNA binding and ligand binding domains, and exerts a significant role in activating the transcription of certain genes (1). Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha (2). Phosphorylation of ER alpha at Serine 118 and ER alpha at Serine 167 affects survival in estrogen receptor (ER)-positive breast cancer and could be helpful in distinguishing patients who are likely to benefit from endocrine therapy alone from those who are not (3). |
TGF Beta Signaling Pathway
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Western blot - Estrogen Receptor alpha (phospho S167) antibody [EPR2163Y]; All lanes : Anti-Estrogen Receptor alpha (phospho S167) antibody [EPR2163Y] at 1/1000 dilution.Lane 1 : MCF-7 cell lysate, untreated.Lane 2 : MCF-7 cell lysate, treated with Lambda Phosphatase.Lysates/proteins at 10 µg per lane.Secondary.HRP-conjugated goat anti-rabbit at 1/2000 dilution.Predicted band size : 66 kDa.Observed band size : 66 kDa.