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Anti-GRIA1 PHOSPHO Antibody EPR2148
Also for GRIA1 (NM_000827)
|A phospho-specific peptide corresponding to residues surrounding Serine 845 of human GluR1 was used as an immunogen. The antibody only detects GluR1 phosphorylated on Serine 845.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens glutamate receptor, ionotropic, AMPA 1 (GRIA1), transcript variant 1|
|GluA1; GLUH1; GLUR1; GLURA; HBGR1|
Entrez Gene 2890 Human
Entrez Gene 14799 Mouse
Entrez Gene 50592 Rat
|Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3). Phosphorylation of the GluR1 subunit on serine 845 by PKA is required for PKA-induced increases in ?-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor cell-surface expression because it promotes receptor insertion and decreases receptor endocytosis. Furthermore, dephosphorylation of GluR1 serine 845 triggers NMDA-induced AMPA receptor internalization (4). |
|TransmembraneIon Channels: Glutamate ReceptorsDruggable Genome Neuroactive ligand-receptor interactionLong-term potentiationLong-term depressionAmyotrophic lateral sclerosis (ALS)|
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Western blot - Glutamate Receptor 1 (AMPA subtype) (phospho S845) antibody [EPR2148]; All lanes : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S845) antibody [EPR2148] at 1/20000 dilution.Lane 1 : Rat brain lysate, untreated.Lane 2 : Rat brain lysate treated with Lambda Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 102 kDa.Observed band size : 106 kDa .