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Home Antibody All anti-PEBP1 antibodies

Anti-PEBP1 Antibody EPR2875Y

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SKU Description Amount Price Availability*  
TA301294
  • Rabbit Monoclonal Antibody against PEBP1 (Clone EPR2875Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400913) , 20ug Explanation
100ul 325 In Stock
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WB(2)
IHC(1)
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Also for PEBP1 (NM_002567)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RKIP was used as an immunogen.
Clone NameEPR2875Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsICC: 1:100; IHC-P: 1:250 - 1:500; IHC-Fr: Use at an assay dependent concentration; WB: 1:1000 - 1:5000; IP: 1:10; ICC/IF: Use at an assay dependent concentration
Predicted MW Explanation 21 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens phosphatidylethanolamine binding protein 1 (PEBP1)
Alternative NameHCNP; HCNPpp; HEL-210; HEL-S-34; PBP; PEBP; PEBP-1; RKIP
Database LinkNP_002558
Entrez Gene 5037 Human
Entrez Gene 23980 Mouse
Entrez Gene 29542 Rat
FunctionRaf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine-binding protein (PEBP) family. It is an inhibitor of the Raf/MEK/MAP kinase signaling cascade and is a suppressor of cancer metastasis (1). RKIP is involved in neural development, cardiac function and spermatogenesis and appears to have serine protease activity. The inhibition Raf-1-mediated phosphorylation of MEK results from RKIP binding to Raf-1. Dysregulated RKIP expression has the potential to contribute to pathophysiological processes including Alzheimer's disease and diabetic nephropathy (2). RKIP represents a novel effector of signal transduction pathways leading to apoptosis and a prognostic marker of the pathogenesis of human cancer cells and tumors (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PBP antibody [EPR2875Y]; All lanes : Anti-PBP antibody [EPR2875Y] at 1/5000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : A549 cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : A431 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 21 kDa.Observed band size : 21 kDa.
WB Image
Western blot - Anti-PBP antibody [EPR2875Y]; Anti-PBP antibody [EPR2875Y] at 1/5000 dilution + Human PBP full length protein at 0.1 ug.Secondary.Goat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilution.developed using the ECL technique.Performed under reducing conditions.Exposure time : 30 seconds
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PBP antibody [EPR2875Y]; Staining of formalin-fixed, paraffin-embedded human brain tissue using 1/250 TA301294.

 

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