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Home Antibody All anti-TTR antibodies

Anti-TTR Antibody EP2929Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301271
  • Rabbit Monoclonal Antibody against TTR (Clone EP2929Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400134) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for TTR (NM_000371)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human Transthyretin was used as an immunogen.
Clone NameEP2929Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2500 - 1:5000; IP: 1:60; IHC-P: 1:250 - 1:500; ICC: 1:100; FC: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens transthyretin (TTR)
Alternative NameCTS; CTS1; HEL111; HsT2651; PALB; TBPA
Database LinkNP_000362
FunctionTransthyretin (prealbumin/TTR) is a hormone-binding protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Transthyretin concentrations are disproportionately high in human ventricular CSF. It is reported to be either selectively transported across or synthesized within the blood-CSF barrier (3). Over 80 different disease-causing mutations in transthyretin have been reported. The vast majority is inherited in an autosomal dominant manner and is related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. A small portion of transthyretin mutations are apparently non-amyloidogenic (4). The human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble transthyretin fibrils (2). Transthyretin has a structural complementarity to double-helical DNA, where the proposed binding site is composed of two symmetry-related beta-sheets containing a pair of helically disposed arms (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Prealbumin antibody [EP2929Y]; All lanes : Anti-Prealbumin antibody [EP2929Y] at 1/5000 dilution.Lane 1 : human heart lysate.Lane 2 : human placenta lysate.Lane 3 : human brain lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 16 kDa.Observed band size : 16 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Prealbumin antibody [EP2929Y]; TA301271 at 1/250 dilution staining Prealbumin in human liver by Immunohistochemistry, Paraffin-embedded tissue.

 

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