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Home Antibody All anti-B2M antibodies

Anti-B2M Antibody EP2978Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301264
  • Rabbit Monoclonal Antibody against B2M (Clone EP2978Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401311) , 20ug
100ul 325 In Stock
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WB(1)
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Also for B2M (NM_004048)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human beta-2-microglobulin was used as an immunogen.
Clone NameEP2978Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:40; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens beta-2-microglobulin (B2M)
Alternative Namebeta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin
Database LinkNP_004039
FunctionBeta-2-microglobulin (B2M) is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (1). It is a major component forming amyloid deposits in patients with hemodialysis-associated amyloidosis (HAA), a serious complication of long-term hemodialysis (2). B2M is found to contain two antiparallel beta-sheets, each of four beta-strands with the beta-sheets being connected by a single disulfide linkage. No evidence for any regular helical structure is found (3). B2M is an example of a low molecular weight serum protein, with a prominent beta-pleated sheet structure, that may adopt the fibrillar configuration of amyloid in certain pathologic states (4).
Related Pathway

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WB Image
Western blot - beta 2 Microglobulin antibody [EP2978Y]; All lanes : Anti-beta 2 Microglobulin antibody [EP2978Y] at 1/200000 dilution.Lane 1 : Raji cell lysate.Lane 2 : U937 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : Human bone marrow lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP-labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 14 kDa.Observed band size : 14 kDa.

 

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