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Home All anti-SUFU antibodies
Anti-SUFU Antibody EPR1206Y
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for SUFU (NM_016169)
OriGene Data
| A synthetic peptide corresponding to peptides on the N-terminus o f human SuFu was used as an immunogen. |
| EPR1206Y |
IgG |
| Human |
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| WB, IHC |
WB: 1: 1000~2000; IHC: 1: 100; FC: 1: 120; IP: 1:50 |
| 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens suppressor of fused homolog (Drosophila) (SUFU), transcript variant 1 |
| PRO1280; SUFUH; SUFUXL |
| NP_057253 |
| The Hedgehog (Hh) signaling pathway has conserved roles in development of species ranging from Drosophila to humans. Human supressor of fused Su(Fu) acts as a negative regulator in the hedgehog signaling (SHH) pathway by down-regulating GLI1-mediated transactivation of target genes (1). Su(fu) was found to repress activity of the zinc-finger transcription factor Gli, which mediates Hedgehog signaling in vertebrates, and to physically interact with Gli, Gli2 and Gli3 (2). The sonic hedgehog signaling pathway directs the embryonic development of diverse organisms and is disrupted in a variety of malignancies. Several of mutations encode truncated proteins that are unable to export the GLI transcription factor from nucleus to cytoplasm, resulting in the activation of SHH signaling. SUFU is a newly identified tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway through a newly identified mechanism (3). |
Hedgehog signaling pathway |
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* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis on (A) HeLa and (B) Human kidney lysate using anti-SuFu, dilution 1:2000.
IHC Image
Immunohistochemical analysis of paraffin-embedded human testis using anti-SuFu.
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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