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Home Antibody All anti-REST antibodies

Anti-REST Antibody EPR2436Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301255
  • Rabbit Monoclonal Antibody against REST (Clone EPR2436Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417192) , 20ug Explanation
100ul 325 In Stock
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human REST was used as an immunogen.
Clone NameEPR2436Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000; FC: 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens RE1-silencing transcription factor (REST), transcript variant 1
Alternative NameNRSF; XBR
Database LinkNP_005603
Entrez Gene 5978 Human
FunctionREST (NRSF/RE1) is a vertebrate silencer protein that potentially regulates a large battery of cell type-specific genes, and therefore may function as a master negative regulator of neurogenesis (1). It is a zinc finger transcription factor that during early embryogenesis is required to repress a subset of neuron-specific genes in non-neural tissues and undifferentiated neural precursors. Changes in REST splicing pattern are suggested to possibly result from altered levels of splicing factors reflecting the formation and/or progression of neuroblastoma tumors (2). REST restricts expression of a large set of genes to neurons by suppressing their expression in non-neural tissues. Its repression involves two distinct repressor proteins, CoREST and mSin3A (3). REST and CoREST together, mediate repression of the type II sodium channel promoter in nonneural cells, and the REST-CoREST complex may mediate long-term repression essential to maintenance of cell identity (4).
Related PathwayTranscription Factors Huntington's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - REST / NRSF antibody [EPR2436Y]; All lanes : Anti-REST / NRSF antibody [EPR2436Y] at 1/2000 dilution.Lane 1 : Raji cell lysate.Lane 2 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 132 kDa.Observed band size : 160 kDa .

 

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