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Anti-REST Antibody EPR2436Y
Also for REST (NM_005612)
|A synthetic peptide corresponding to residues near the N-terminus of human REST was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:2000; FC: 1:100
|Does not react with Mouse, Rat. Is unsuitable for ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens RE1-silencing transcription factor (REST), transcript variant 1|
|REST (NRSF/RE1) is a vertebrate silencer protein that potentially regulates a large battery of cell type-specific genes, and therefore may function as a master negative regulator of neurogenesis (1). It is a zinc finger transcription factor that during early embryogenesis is required to repress a subset of neuron-specific genes in non-neural tissues and undifferentiated neural precursors. Changes in REST splicing pattern are suggested to possibly result from altered levels of splicing factors reflecting the formation and/or progression of neuroblastoma tumors (2). REST restricts expression of a large set of genes to neurons by suppressing their expression in non-neural tissues. Its repression involves two distinct repressor proteins, CoREST and mSin3A (3). REST and CoREST together, mediate repression of the type II sodium channel promoter in nonneural cells, and the REST-CoREST complex may mediate long-term repression essential to maintenance of cell identity (4). |
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Western blot - REST / NRSF antibody [EPR2436Y]; All lanes : Anti-REST / NRSF antibody [EPR2436Y] at 1/2000 dilution.Lane 1 : Raji cell lysate.Lane 2 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 132 kDa.Observed band size : 160 kDa .