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Home Antibody All anti-EPS15L1 antibodies

Anti-EPS15L1 Antibody EP1146Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA301237 Rabbit Monoclonal Antibody against EPS15L1 (Clone EP1146Y) 100ul $325 In Stock
LC402859 EPS15L1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human EPS15R was used as an immunogen.
Clone NameEP1146Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:10000 - 1:20000; FC: 1:20; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 94 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens epidermal growth factor receptor pathway substrate 15-like 1 (EPS15L1), transcript variant 2
Alternative NameEPS15R
Database LinkNP_067058
Entrez Gene 58513 Human
Entrez Gene 13859 Mouse
Entrez Gene 361120 Rat
FunctionEPS15 and EPS15R are substrates of the epidermal growth factor (EGF) receptor kinase that are characterized by the presence of a protein:protein interaction domain, the EH domain, and by their ability to bind to the clathrin adaptor protein complex adaptor protein 2. Evidence suggests that eps15 and eps15R are involved in endocytosis (1). The most striking difference between these two related proteins is that Eps15R is also found in the nucleus, whereas Eps15 is excluded from this compartment at steady state (2). Eps15R plays a key role in clathrin-mediated endocytosis of transmembrane receptors. Using a mutational approach, it has been found that the second ubiquitin-interacting motif (UIM) of Eps15 and Eps15R is essential for their ubiquitination (3).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - EPS15R antibody [EP1146Y]; All lanes : Anti-EPS15R antibody [EP1146Y] at 1/20000 dilution.Lane 1 : HeLa cell lysates.Lane 2 : 293T cell lysates.Lane 3 : SHSY5Y cell lysates.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 94 kDa.Observed band size : 76,108,125 kDa .

IF Image
Immunocytochemistry/ Immunofluorescence - EPS15R antibody [EP1146Y]; TA301237 at 1/100-1/250 dilution staining EPS15R in A431 cells by Immunofluorescence.


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