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Anti-CTNNB1 Phospho Antibody EP1905Y
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Also for CTNNB1 (NM_001904)
|A phospho specific peptide corresponding to residues surrounding threonine 41 and 45 of human Beta-catenin was used as an immunogen. This antibody detects Beta-catenin phosphorylated on threonine 41 and/or 45.|
||WB: 1: 10,000~20,000; IP: 1:20
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1|
|armadillo; CTNNB; MRD19|
|Beta-catenin is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation (1). Beta-catenin is phosphorylated at four serine and threonine residues at the N-terminus (2). Ser 45 is phosphorylated by CK1, and is thought to be a priming site for the phosphorylation by glycogen synthase kinase-3 (GSK-3) of the remaining three residues, Thr 41, Ser 37, and Ser 33 (2). Wnt signaling antagonizes the action of GSK-3, which in subsequent phosphorylation steps, leads to its degradation (3). Mutations in the -catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas (4). |
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot analysis on 293T cell lysates using anti-Phospho- β-catenin (pT41/pT45), 1:20,000 dilution. Cells were either (A) untreated (B) treated with calyculin A.