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Home All anti-CTNNB1 antibodies
Anti-CTNNB1 Phospho Antibody EP1905Y
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for CTNNB1 (NM_001904)
OriGene Data
| A phospho specific peptide corresponding to residues surrounding threonine 41 and 45 of human Beta-catenin was used as an immunogen. This antibody detects Beta-catenin phosphorylated on threonine 41 and/or 45. |
| EP1905Y |
IgG |
| Human |
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| WB |
WB: 1: 10,000~20,000; IP: 1:20 |
| 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1 |
| armadillo; CTNNB; MRD19 |
| NP_001895 |
| Beta-catenin is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation (1). Beta-catenin is phosphorylated at four serine and threonine residues at the N-terminus (2). Ser 45 is phosphorylated by CK1, and is thought to be a priming site for the phosphorylation by glycogen synthase kinase-3 (GSK-3) of the remaining three residues, Thr 41, Ser 37, and Ser 33 (2). Wnt signaling antagonizes the action of GSK-3, which in subsequent phosphorylation steps, leads to its degradation (3). Mutations in the -catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas (4). |
Adherens junction Adipogenesis Focal Adhesion Melanogenesis TGF Beta Signaling Pathway Wnt Signaling Pathway |
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* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis on 293T cell lysates using anti-Phospho- β-catenin (pT41/pT45), 1:20,000 dilution. Cells were either (A) untreated (B) treated with calyculin A.
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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