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Home Antibody All anti-FYB antibodies

Anti-FYB Antibody EPR2547Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301212
  • Rabbit Monoclonal Antibody against FYB (Clone EPR2547Y)
100ul $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human FYB was used as an immunogen.
Clone NameEPR2547Y IsotypeIgG
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 1: 100~250; ICC: 1: 100~250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Rat

Reference Data

Target NameHomo sapiens FYN binding protein (FYB), transcript variant 2
Alternative NameADAP; PRO0823; SLAP-130
Database LinkNP_955367
FunctionFYN-binding protein (FYB) is an adapter protein for Fyn and SLP-76 signaling cascades in T cells. A hematopoietic protein, FYB associates with p59fyn and becomes tyrosine-phosphorylated in response to receptor ligation. FYB has been associated to modulation of IL-2 expression in T cells and platelet activation (3). Fyn (p59Fyn) is a 59 kDa member of the Src family of tyrosine kinases. The carboxy terminus of Fyn shares extensive amino acid sequence homology with Src, but is very different within the amino-terminal 81 amino acid residues. The Fyn protein is synthesized and N-myristoylated on cytosolic polysomes and then rapidly targeted to the plasma membrane, where it is palmitoylated. Fyn's biological functions are diverse and include signaling via the T cell receptor, regulation of brain function and adhesion mediated signaling (2, 3). FYN-binding protein (FYB) is an adapter protein for Fyn and SLP-76 signaling cascades in T cells. A hematopoietic protein, FYB associates with p59fyn and becomes tyrosine-phosphorylated in response to receptor ligation. FYB has been associated to modulation of IL-2 expression in T cells and platelet activation (3).
Related Pathway
Hemostasis

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WB Image
Western blot - FYB antibody [EPR2547Y]; Anti-FYB antibody [EPR2547Y] at 1/500 dilution + TF-1 lysate at 10 µg.Secondary.Goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 85 kDa.Observed band size : 120 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FYB antibody [EPR2547Y]; TA301212, at 1/100 dilution, staining FYB in human tonsil by immunohistochemistry using paraffin-embedded tissue.

 

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