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Anti-TNFRSF1A Antibody EP1651AY

WB(1)

Gene Name Homo sapiens tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) Synonyms: CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55; Immunogen A synthetic peptide corresponding to the extracellular portion of human TNFR1 was used as immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name EP1651AY Isotype IgG Species Reactivity Human Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB Suggested Dilutions WB: 1:500; FC: 1:30 Background Tumor necrosis factor receptor 1 (TNFR1) is a receptor for tumor necrosis factor alpha (TNF-?), a mulitifunctional proinflammatory cytokine. Produced in activated monocytes, TNF-? has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function (1). TNFR1 is activated by binding to TNF- ? or homotrimeric lymphotoxin-?, which leads to recruitment of caspase 8 to the activated receptor by FADD. This formation of death inducing signaling complex (DISC) lead to caspase 8 proteolytic activation and cascade of caspases mediating apoptosis (2). Related Pathway Apoptosis Cytokine-cytokine receptor interaction MAPK signaling pathway

Related Lysate from OriGene • Transient overexpression lysate of tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • TNFRSF1A - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • TNFRSF1A - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Tnfrsf1a - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • TNFRSF1A - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Tnfrsf1a - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) as transfection-ready DNA • Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) , Myc-DDK-tagged • Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), mGFP tagged • GFP-tagged ORF clone of Homo sapiens tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) as transfection-ready DNA Related cDNA Clones • Homo sapiens tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) as transfection-ready DNA • Homo sapiens tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)