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Home Antibody All anti-TNFRSF1A antibodies

Anti-TNFRSF1A Antibody EP1651AY

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SKU Description Amount Price Availability*  
TA301202
  • Rabbit Monoclonal Antibody against TNFRSF1A (Clone EP1651AY)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400435) , 20ug Explanation
100ul 325 In Stock
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WB(1)
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Also for TNFRSF1A (NM_001065)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to the extracellular portion of human TNFR1 was used as immunogen.
Clone NameEP1651AY IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500; FC: 1:30
Predicted MW Explanation 51 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A)
Alternative NameCD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
Database LinkNP_001056
Entrez Gene 7132 Human
FunctionTumor necrosis factor receptor 1 (TNFR1) is a receptor for tumor necrosis factor alpha (TNF-?), a mulitifunctional proinflammatory cytokine. Produced in activated monocytes, TNF-? has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function (1). TNFR1 is activated by binding to TNF- ? or homotrimeric lymphotoxin-?, which leads to recruitment of caspase 8 to the activated receptor by FADD. This formation of death inducing signaling complex (DISC) lead to caspase 8 proteolytic activation and cascade of caspases mediating apoptosis (2).
Related PathwaySecreted ProteinTransmembraneTranscription FactorsDruggable Genome MAPK signaling pathwayCytokine-cytokine receptor interactionApoptosisAdipocytokine signaling pathwayAlzheimer's diseaseAmyotrophic lateral sclerosis (ALS)More Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - TNF Receptor I antibody [EP1651AY]; Anti-TNF Receptor I antibody [EP1651AY] at 1/500 dilution + human brain tissue lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : 51 kDa.

 

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