Invalid object name 'antibody_LocusMapping'. Anti-CTNNB1 Antibody, EP690Y - OriGene
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Anti-CTNNB1 Antibody EP690Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301191
  • Rabbit Monoclonal Antibody against CTNNB1 (Clone EP690Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419662) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for CTNNB1 (NM_001904)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human ?-catenin was used as an immunogen.
Clone NameEP690Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500; FC: 1:200
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1
Alternative Namearmadillo; CTNNB; MRD19
Database LinkNP_001895
Function?-catenin is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation (1). -catenin is phosphorylated at four serine and threonine residues at the N-terminus (2). Ser 45 is phosphorylated by CK1, and is thought to be a priming site for the phosphorylation by glycogen synthase kinase-3 (GSK-3) of the remaining three residues, Thr 41, Ser 37, and Ser 33 (2). Wnt signaling antagonizes the action of GSK-3, which in subsequent phosphorylation steps, leads to its degradation (3). Mutations in the -catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas (4).
Related Pathway
Adherens junction
Adipogenesis
Focal Adhesion
Melanogenesis
TGF Beta Signaling Pathway
Wnt Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - beta Catenin antibody [EP690Y]; Anti-beta Catenin antibody [EP690Y] at 1/500 dilution + A431 cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 86 kDa.Observed band size : 86 kDa.

 

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