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Home All anti-TP53 antibodies
Anti-TP53 Antibody EP1889Y
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for TP53 (NM_000546)
OriGene Data
| A synthetic phospho-peptide corresponding to residues surrounding Serine 392 of human p53 was used as an immunogen. The antibody will detect p53 phosphorylation on Serine 392. |
| EP1889Y |
IgG |
| Human |
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| WB, IHC |
WB: 1:5000; IHC: 1: 100~250; ICC: 1: 100~250; IP: 1:40 |
| 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens tumor protein p53 (TP53), transcript variant 1 |
| BCC7; LFS1; P53; TRP53 |
| NP_000537 |
| p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair. Various serine/threonine kinases (ATM, p38, Chk) has been limplicated to p53 phospholyation. Phospholyation at serine 392 has been linked to p53 activation. Phospholyation on serine 392 also induces p53 interaction with NF kappa beta - p65 in mouse and inhibition with Cdc2 and MDM2 in human (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers. p53 is frequently mutated or inactivated in about 60% of cancers. |
Apoptosis Cell cycle Delta-Notch Signaling Pathway MAPK signaling pathway Senescence and Autophagy TGF Beta Signaling Pathway Wnt Signaling Pathway |
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis on HepG2 cell lysate using anti-phospho-p53 (pS392), 1:10,000 dilution. Cells were either (A) untreated or (B) treated with etoposide.
IHC Image
Immunohistochemical analysis of paraffin-embedded human ovarian adenocarcinoma using anti-Phospho-p53
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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