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Home Antibody All anti-HMOX1 antibodies

Anti-HMOX1 Antibody EPR1390Y

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SKU Description Amount Price Availability*  
TA301177 Rabbit Monoclonal Antibody against HMOX1 (Clone EPR1390Y) 100ul $325 In Stock
LC400777 HMOX1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
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Also for HMOX1 (NM_002133)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding the N-terminus of human HO-1 was used as an immunogen.
Clone NameEPR1390Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1: 10,000; ICC: 1: 100; IP: 1:20
Predicted MW Explanation 33 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens heme oxygenase (decycling) 1 (HMOX1)
Alternative NamebK286B10; HMOX1D; HO-1; HSP32
Database LinkNP_002124
Entrez Gene 3162 Human
Entrez Gene 15368 Mouse
Entrez Gene 24451 Rat
FunctionStressed mammalian cells up-regulate heme oxygenase 1 (HO-1), which catabolizes heme to biliverdin, carbon monoxide, and free iron. Results provide genetic evidence that up-regulation of HO-1 serves as an adaptive mechanism to protect cells from oxidative damage during stress (1). When cells are injured they release their contents, resulting in a local accumulation of free heme proteins and heme. HO-1 plays a crucial role in the inflammatory process during wound healing (2). TNFalpha accelerates inflammatory responses by down-regulating HO-1 expression in human monocytes. TNF antagonists may block this TNF-dependent suppression of HO-1 expression, resulting in an amelioration of inflammation (3).
Related PathwayTransmembraneDruggable Genome Porphyrin and chlorophyll metabolism

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Heme Oxygenase 1 antibody [EPR1390Y]; All lanes : Anti-Heme Oxygenase 1 antibody [EPR1390Y] at 1/2000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : A549 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 33 kDa.Observed band size : 33 kDa.Additional bands at : 125-130 kDa,30 kDa,48 kDa,52 kDa. We are unsure as to the identity of these extra bands.
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