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Anti-HMOX1 Antibody EPR1390Y
Also for HMOX1 (NM_002133)
|A synthetic peptide corresponding to residues surrounding the N-terminus of human HO-1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1: 10,000; ICC: 1: 100; IP: 1:20
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Homo sapiens heme oxygenase (decycling) 1 (HMOX1)|
|bK286B10; HMOX1D; HO-1; HSP32|
|Stressed mammalian cells up-regulate heme oxygenase 1 (HO-1), which catabolizes heme to biliverdin, carbon monoxide, and free iron. Results provide genetic evidence that up-regulation of HO-1 serves as an adaptive mechanism to protect cells from oxidative damage during stress (1). When cells are injured they release their contents, resulting in a local accumulation of free heme proteins and heme. HO-1 plays a crucial role in the inflammatory process during wound healing (2). TNFalpha accelerates inflammatory responses by down-regulating HO-1 expression in human monocytes. TNF antagonists may block this TNF-dependent suppression of HO-1 expression, resulting in an amelioration of inflammation (3). |
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Western blot - Heme Oxygenase 1 antibody [EPR1390Y]; All lanes : Anti-Heme Oxygenase 1 antibody [EPR1390Y] at 1/2000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : A549 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 33 kDa.Observed band size : 33 kDa.Additional bands at : 125-130 kDa,30 kDa,48 kDa,52 kDa. We are unsure as to the identity of these extra bands.