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Home Antibody All anti-MET antibodies

Anti-MET PHOSPHO Antibody EP2367Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301175
  • Rabbit Monoclonal Antibody against MET (Clone EP2367Y) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for MET (NM_000245)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 1349 of human Met was used as an immunogen. This antibody detects Met phosphorylated at tyrosine 1349.
Clone NameEP2367Y IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:5000; IHC: 1:50; ICC: 1:50; IP: 1:20
Predicted MW Explanation 156 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), transcript variant 2
Alternative NameAUTS9; c-Met; HGFR; RCCP2
Database LinkNP_000236
Entrez Gene 4233 Human
FunctionMet is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which is a multifunctional cytokine controlling cell growth, morphogenesis, and motility. Met overexpression has been identified in a variety of human cancers (1). Met kinase domain possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. These results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein exhibits homology to laminin B1 (2). Data suggest that RanBP9, functioning as an adaptor protein for the Met tyrosine kinase domain, can augment the HGF-Met signaling pathway and that RanBP9 overexpression may cause constitutive activation of the Ras signaling pathway (2). Interaction of the hepatocyte growth factor (HGF) with its receptor, the Met tyrosine kinase, results in invasive growth, a genetic program essential to embryonic development and implicated in tumor metastasis. Met-mediated invasive growth requires autophosphorylation of the receptor on tyrosines located in the kinase activation loop (Tyr(1234)-Tyr(1235)) and in the tail (Tyr(1349)-Tyr(1356)).
Related PathwayProtein KinaseTransmembraneDruggable Genome Cytokine-cytokine receptor interactionEndocytosisAxon guidanceFocal adhesionAdherens junctionEpithelial cell signaling in Helicobacter pylori infectionMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Met (c-Met) (phospho Y1349) antibody [EP2367Y]; All lanes : Anti-Met (c-Met) (phospho Y1349) antibody [EP2367Y] at 1/10000 dilution.Lane 1 : A431 cell lysate, untreated.Lane 2 : A431 cell lysate, treated with AP.Lysates/proteins at 10 ug per lane.Secondary.HRP-labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 156 kDa.Observed band size : ~150 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Met (c-Met) (phospho Y1349) antibody [EP2367Y]; Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using TA301175 at a dilution of 1/50.

 

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