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Anti-TNFSF9 Antibody EPR1172Y
Also for TNFSF9 (NM_003811)
|A synthetic peptide corresponding to residues near the N-terminus of human 4-1BBL was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500; IHC: 1: 100; ICC: 1: 100; IP: 1:40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9)|
|4-1BB was originally described as a cDNA expressed by activated murine T cells and subsequently demonstrated to encode a member of the tumor necrosis factor receptor family of integral membrane proteins. Recently, a murine ligand for 4-1BB (mu4-1BB-L) was cloned and demonstrated to be a member of an emerging family of ligands with structural homology to tumor necrosis factor. Both monoclonal antibody to hu4-1BB and cells transfected with hu4-1BB-L induced a strong proliferative response in mitogen co-stimulated primary T cells. In contrast, ligation of 4-1BB on T cell clones enhanced activation-induced cell death when triggered by engagement of the TCR/CD3 complex. (1). To reject tumors, T cells must overcome poor tumor immunogenicity and an adverse tumor microenvironment. It has been shown that primary human T cells expressing CD80 and 4-1BBL vigorously respond to tumor cells lacking costimulatory ligands and provoke potent rejection of large, systemic tumors in immunodeficient mice (2). |
Cytokine-cytokine receptor interaction
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Western blot - TNFSF9 antibody [EPR1172Y]; Anti-TNFSF9 antibody [EPR1172Y] at 1/2000 dilution + 293T cell lysate at 10 µg.Secondary.HRP conjugated Goat anti-rabbit at 1/2000 dilution.Predicted band size : 27 kDa.Observed band size : 25 kDa .