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Home Antibody All anti-SOD2 antibodies

Anti-SOD2 Antibody EPR2560Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301157
  • Rabbit Monoclonal Antibody against SOD2 (Clone EPR2560Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400235) , 20ug
100ul $325 Next Day
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WB(1)
IHC(2)
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Also for SOD2 (NM_000636)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human SOD2 was used as an immunogen.
Clone NameEPR2560Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsIHC-Fr: Use at an assay dependent concentration; WB: 1:1000 - 1:2000; IHC-P: 1:100 - 1:250
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens superoxide dismutase 2, mitochondrial (SOD2), transcript variant 1
Alternative NameIPOB; MNSOD; MVCD6
Database LinkNP_000627
FunctionSuperoxide dismutase comprises a family of metalloenzymes that catalyze the oxido-reduction of superoxide anion to H2O2. Manganese superoxide dismutase (SOD2) is encoded by nuclear chromatin, synthesized in the cytosol, and imported posttranslationally into the mitochondrial matrix (1). It has been shown that SOD2 activity in tumor cells is lower than that in their normal counterparts. results suggest that the reduced level of SOD2 activity observed in human tumor cells is not due to a defect in the primary structure of the SOD2 protein, a change in the dosage of the SOD2 gene, or a decrease in the stability of SOD2 mRNA in tumor cells but rather is due to a defect or defects in the expression of the gene (2). SOD2 is one of the major cellular defense enzymes that protects against toxic effects of superoxide radicals. Overexpression of human SOD2 has been shown to inhibit radiation-induced neoplastic transformation, suppress malignancy of cancer cells, and increase tolerance to various toxic agents (3).
Related Pathway

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WB Image
Western blot - Superoxide Dismutase 2 antibody [EPR2560Y]; All lanes : Anti-SOD2 antibody [EPR2560Y] at 1/500 dilution.Lane 1 : Rat brain lysate.Lane 2 : SH-SY5Y lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 25 kDa.Observed band size : 25 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Superoxide Dismutase 2 antibody [EPR2560Y]; TA301157 at 1:100 dilution staining Superoxide Dismutase 2 in human liver tissue sections.
IHC Image
Immunohistochemistry (Frozen sections) - Anti-SOD2 antibody [EPR2560Y]; Immunohistochemical analysis of frozen rat lung tissue taken from rats with monocrotaline-exposure/pneumonectomy, staining SOD2 with TA301157.

 

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