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Anti-SOD2 Antibody EPR2560Y
Also for SOD2 (NM_000636)
|A synthetic peptide corresponding to residues near the N-terminus of human SOD2 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||IHC-Fr: Use at an assay dependent concentration; WB: 1:1000 - 1:2000; IHC-P: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens superoxide dismutase 2, mitochondrial (SOD2), transcript variant 1|
|IPOB; MNSOD; MVCD6|
Entrez Gene 6648 Human
Entrez Gene 20656 Mouse
Entrez Gene 24787 Rat
|Superoxide dismutase comprises a family of metalloenzymes that catalyze the oxido-reduction of superoxide anion to H2O2. Manganese superoxide dismutase (SOD2) is encoded by nuclear chromatin, synthesized in the cytosol, and imported posttranslationally into the mitochondrial matrix (1). It has been shown that SOD2 activity in tumor cells is lower than that in their normal counterparts. results suggest that the reduced level of SOD2 activity observed in human tumor cells is not due to a defect in the primary structure of the SOD2 protein, a change in the dosage of the SOD2 gene, or a decrease in the stability of SOD2 mRNA in tumor cells but rather is due to a defect or defects in the expression of the gene (2). SOD2 is one of the major cellular defense enzymes that protects against toxic effects of superoxide radicals. Overexpression of human SOD2 has been shown to inhibit radiation-induced neoplastic transformation, suppress malignancy of cancer cells, and increase tolerance to various toxic agents (3). |
|Transcription FactorsDruggable Genome Huntington's disease|
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Western blot - Superoxide Dismutase 2 antibody [EPR2560Y]; All lanes : Anti-SOD2 antibody [EPR2560Y] at 1/500 dilution.Lane 1 : Rat brain lysate.Lane 2 : SH-SY5Y lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 25 kDa.Observed band size : 25 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Superoxide Dismutase 2 antibody [EPR2560Y]; TA301157 at 1:100 dilution staining Superoxide Dismutase 2 in human liver tissue sections.
Immunohistochemistry (Frozen sections) - Anti-SOD2 antibody [EPR2560Y]; Immunohistochemical analysis of frozen rat lung tissue taken from rats with monocrotaline-exposure/pneumonectomy, staining SOD2 with TA301157.