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Home Antibody All anti-KDR antibodies

Anti-KDR Antibody EPRER16Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301154
  • Rabbit Monoclonal Antibody against KDR (Clone EPRER16Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400826) , 20ug
100ul 325 In Stock
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WB(1)
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Also for KDR (NM_002253)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in extracellular domain of human KDR/VEGFR2 was used as an immunogen. It is predicted that this antibody does not cross react with other members of VEGF receptor family.
Clone NameEPRER16Y IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:20
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IHC-P.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR)
Alternative NameCD309; FLK1; VEGFR; VEGFR2
Database LinkNP_002244
FunctionThe expression of VEGF and KDR correlates highly with the normal ocular vascularization in humans, but VEGF may also be necessary for nonvascular retinal developmental functions, especially for the coordination of neural retinal development and the preliminary steps of the establishment of the definitive stable retinal vasculature (1). KDR/flk-1 is one of two receptors for vascular endothelial growth factor, a potent angiogenic peptide. KDR/flk-1 is an early marker for endothelial cell progenitors, and its expression is restricted to endothelial cells in vivo (2). Therapeutic angiogenesis is likely to require the administration of factors that complement each other. Activation of the receptor tyrosine kinase KDR/Flk1 by vascular endothelial growth factor (VEGF) is crucial, but molecular interactions of other factors with VEGF and Flk1 have been studied to a limited extent. Activation of KDR/Flt1 by PGF resulted in intermolecular transphosphorylation of Flk1, thereby amplifying VEGF-driven angiogenesis through KDR/Flk1. Even though VEGF and PGF both bind KDR/Flt1, PGF uniquely stimulated the phosphorylation of specific KDR/Flt1 tyrosine residues and the expression of distinct downstream target genes (3).
Related Pathway
Cytokine-cytokine receptor interaction
Focal Adhesion

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-VEGF Receptor 2 antibody [EPRER16Y]; Anti-VEGF Receptor 2 antibody [EPRER16Y] at 1/500 dilution + Human placenta lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 151 kDa.Observed band size : 210,230 kDa .

 

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