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Home All anti-KRT5 antibodies
Anti-KRT5 Antibody EPR1600Y
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for KRT5 (NM_000424)
OriGene Data
| A synthetic peptide corresponding to residues in the head region of human cytokeratin 5 was used as an immunogen. |
| EPR1600Y |
IgG |
| Human |
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| WB, IHC |
WB: 1: 10,000; IHC: 1: 100; ICC: 1:250; IP: 1:60 |
| 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens keratin 5 (KRT5) |
| CK5; DDD; EBS2; K5; KRT5A |
| NP_000415 |
| Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. The mitotically active basal layers of most stratified squamous epithelia express 10 to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin CK-5 and its corresponding partner, type I keratin CK-14, both of which are essential for the formation of 8-nm filaments (1). CK-5 and calretinin have been useful in different studies as immunohistochemical markers suggestive of mesothelioma, and their expression is analyzed for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin (2). Loss-of-function mutations in the keratin 5 gene (KRT5) affected family members and in six unrelated patients with Dowling-Degos disease (DDD), an autosomal dominant genodermatosis. This suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage (3). |
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* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis on A431 cell lysate using anti-CK-5, dilution 1:10,000.
IHC Image
Immunohistochemical analysis of paraffin-embedded human squamous cervical carcinoma using anti-CK-5.
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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