Search:     All Products Assays Human cDNA clone, untagged Human cDNA clone, tagged RNAi 3'-UTR Clone Human Primer Mouse cDNA clone, untagged Mouse cDNA clone, tagged Rat ORF clone, untagged Rat ORF clone, tagged Virus ORF clone, tagged Mouse Primer qPCR Standard Proteins Mass Spec Standard Antibodies Lysate MicroRNA Expression Plasmids MicroRNA primer pairs MicroRNA template standards Other Products

Anti-STAT3 Antibody EPR787Y

WB(1)

Gene Name Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3 Synonyms: APRF; HIES Immunogen A synthetic peptide corresponding to N-terminus residues of human Stat3 was used as immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name EPR787Y Isotype IgG Species Reactivity Human, Mouse, Rat Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB Suggested Dilutions WB: 1:500; ICC: 1:50; IP: 1:30 Background Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding While, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 (4) Related Pathway Adipogenesis Delta-Notch Signaling Pathway EGFR1 Signaling Pathway Jak-STAT signaling pathway TGF Beta Signaling Pathway

Related Lysate from OriGene • Transient overexpression lysate of signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • STAT3 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • STAT3 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Stat3 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • STAT3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Stat3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3 as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3 as transfection-ready DNA • Myc-DDK-tagged ORF clone of Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3 as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3 as transfection-ready DNA Functional Proteins • STAT3 (Signal Transducer and Activator of Transcription 3) 10,000 units • STAT3 (Signal Transducer and Activator of Transcription 3) 25,000 units

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)