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Home Antibody All anti-CAV1 antibodies

Anti-CAV1 PHOSPHO Antibody EPR2288Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301128
  • Rabbit Monoclonal Antibody against CAV1 (Clone EPR2288Y) (Phospho-specific)
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA phospho specifici peptide corresponding to residues surrounding tyrosine 14 of human caveolin-1 was used as an immunogen. This antibody detects caveolin-1 phosphorylated at tyrosine 14.
Clone NameEPR2288Y IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:2000 - 1:5000; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens caveolin 1, caveolae protein, 22kDa (CAV1), transcript variant 1
Alternative NameBSCL3; CGL3; MSTP085; PPH3; VIP21
Database LinkNP_001744
FunctionCaveolins make up a family of proteins that are principal structural components of hairpin-like domains in the plasma membrane (1). It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Three members of caveolins (caveolin-1, -2 and -3) have been identified, possessing different tissue distributions (2). Caveolins interact with multiple signaling molecules, such as the G-protein alpha subunit (1), tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS (2,3). Caveolin-1 has been implicated in the pathogenesis of mammary epithelial cell hyperplasia (4). Endothelial cell (EC) migration is a critical event during multiple physiological and pathological processes. The phosphorylatable Tyr14 residue of caveolin-1 is required for polarization of the protein during transmigration but does not alter polarization during planar movement.
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
Hemostasis
TGF Beta Signaling Pathway

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WB Image
Western blot - Caveolin 1 (phospho Y14) antibody [EPR2288Y]; All lanes : Anti-Caveolin 1 (phospho Y14) [EPR2288Y] antibody at 1/2000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HeLa cell lysate treated with pervanadate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 20 kDa.Observed band size : 22 kDa .

 

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