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Anti-CCND1 Antibody EPR2241
Also for CCND1 (NM_053056)
|A synthetic peptide corresponding to residues near the C-terminus of human Cyclin D1 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:10000; IP: 1:40; ICC/IF: 1:100; IHC-P: 1:100
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt.
|Homo sapiens cyclin D1 (CCND1)|
|BCL1; D11S287E; PRAD1; U21B31|
|Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (5). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (6-7) |
Jak-STAT signaling pathway
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot - Anti-Cyclin D1 antibody [EPR2241]; .developed using the ECL technique.Performed under reducing conditions.Predicted band size : 34 kDa.Exposure time : 3 minutes
Western blot - Anti-Cyclin D1 antibody [EPR2241]; Anti-Cyclin D1 antibody [EPR2241] at 1/10000 dilution + MCF7 cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 34 kDa.
Other-Anti-Cyclin D1 antibody [EPR2241](TA301123); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin D1 antibody [EPR2241]; Immunohistochemical analysis of paraffin-embedded Human mantle cell lymphoma tissue labelling Cyclin D1 with TA301123 at 1/100 dilution.