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Anti-GRM5 Antibody EPR2425Y


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SKU Description Amount Price Availability*  
TA301102 Rabbit Monoclonal Antibody against GRM5 (Clone EPR2425Y) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human mGluR5
Clone NameEPR2425Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:5000; IHC: 1:250; ICC: 1: 100; FC: 1: 10
Predicted MW Explanation 132 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens glutamate receptor, metabotropic 5 (GRM5), transcript variant b
Alternative NameGPRC1E; mGlu5; MGLUR5; PPP1R86
Database LinkNP_000833
Entrez Gene 2915 Human
Entrez Gene 108071 Mouse
Entrez Gene 24418 Rat
FunctionL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. It has been suggested that mGluR5 may be the primary high affinity ACPD receptor in CA1 neurons (1). Also, neuroprotection by mGluR system has been linked to the modulation of both the free radical nitric oxide (NO) and programmed cell death (PCD). Activation of group I mGluR subtypes utilized an effective, "upstream" mechanism for the inhibition of cysteine protease activity that offered an enhanced level of neuroprotection through both the preservation of genomic DNA integrity and the maintenance of PS membrane asymmetry (2). It has also been shown that activation of mGluRs enhances formation of an mGluR-Homer-PIKE-L complex, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Our findings indicate that this complex mediates the well-known ability of agonists of mGluR5 to prevent neuronal apoptosis (3).
Related PathwayGPCRTransmembraneDruggable Genome Calcium signaling pathwayNeuroactive ligand-receptor interactionGap junctionLong-term potentiationLong-term depressionHuntington's diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Metabotropic Glutamate Receptor 5 antibody [EPR2425Y]; Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y] at 1/10000 dilution + mouse brain lysate at 10 ug.Secondary.Goat anti-rabbit-HRP at 1000 .developed using the ECL technique.Predicted band size : 132 kDa.Observed band size : 140-150 kDa .Additional bands at : >250 kDa (possible dimer).

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Metabotropic Glutamate Receptor 5 antibody [EPR2425Y]; Human brain tissue with TA301102 at 1/250 dilution.


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