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Anti-STAT3 Antibody EP2147Y
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Also for STAT3 (NM_213662)
|A synthetic phospho-peptide corresponding to residues surrounding tyrosine 727 of human Stat3 was used as immunogen.|
|WB, IHC, IF
||WB: 1: 10,000; IHC: 1: 100; ICC: 1: 100; IP: 1:40
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3|
|Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding While, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 (4) |
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
TGF Beta Signaling Pathway
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Western blot analysis on HeLa cell lysates using anti-Phospho-Stat3 (pY705), 1:20,000 dilution. Cells were either (A) untreated (B) treated with IFN-α
Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using anti-Phospho STAT3 (pY705).
Immunofluorescent staining of HeLa cells using anti-Phospho STAT3 (pY705)