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Anti-LCK Antibody EP2158Y
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|A synthetic phospho-peptide corresponding to residues surrounding Tyrosine 505 of human LCK was used as immunogen.|
||WB: 1:: 1,000~10,000
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens lymphocyte-specific protein tyrosine kinase (LCK), transcript variant 2|
|LSK; p56lck; pp58lck; YT16|
|The human T-cell or lymphocyte specific gene Lck/p56 is a member of the Src family of non-receptors tyrosine kinase. Mostly expressed in T cells, Lck has been shown to be critical for the normal development of T lymphocytes (1). Additionally, the N-terminal region of the tyrosine kinase Lck interacts with the cytoplasmic domains of CD4 and CD8 (2). Autophosphorylation at Tyr-394 appears to be required for maximum catalytic activity (3) but it can also be suppressed by phosphorylation of the carboxyl-terminal tyrosine Tyr-505 (4). |
Delta-Notch Signaling Pathway
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Western blot analysis on Jurkat cell lysates using anti-Phospho-LCK (pY505), 1:10,000 dilution. Cells were either (A) untreated (B) treated with AP.