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Anti-PDGFRB Phospho Antibody EP2135Y
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Also for PDGFRB (NM_002609)
|A phospho specific peptide corresponding to residues surrounding Tyrosine 740 of human PDGF-Receptor ? was used as an immunogen. This antibody detects PDGF-Receptor ? phosphorylated at Tyrosine 740|
||WB: 1: 1000; ICC: 1: 100
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB)|
|CD140B; IBGC4; JTK12; PDGFR; PDGFR-1; PDGFR1|
|Human platelet-derived growth factor (PDGF) receptor is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Two major isoforms exist, PDGF receptor-? and PDGF receptor-?. PDGF receptor-? can only bind two specific PDGF isoforms, PDGF-? and PDGF-? (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others. Both Tyrosine 751 and 740 is required for PDGFR-? mediated PI3 kinase activation. In particular, Tyrosine 751 is the docking site for P13 kinase (4). |
Cytokine-cytokine receptor interaction
MAPK signaling pathway
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Western blot analysis on NIH 3T3 cell lysates using anti-Phospho-PDGF receptor β (pY740), 1:2000 dilution. Cells were either (A) untreated (B) treated with PDGF