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Home All anti-PDGFRB antibodies
Anti-PDGFRB Phospho Antibody EP2135Y
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for PDGFRB (NM_002609)
OriGene Data
| A phospho specific peptide corresponding to residues surrounding Tyrosine 740 of human PDGF-Receptor ? was used as an immunogen. This antibody detects PDGF-Receptor ? phosphorylated at Tyrosine 740 |
| EP2135Y |
IgG |
| Human, Mouse |
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| WB |
WB: 1: 1000; ICC: 1: 100 |
| 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB) |
| CD140B; IBGC4; JTK12; PDGFR; PDGFR-1; PDGFR1 |
| NP_002600 |
| Human platelet-derived growth factor (PDGF) receptor is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Two major isoforms exist, PDGF receptor-? and PDGF receptor-?. PDGF receptor-? can only bind two specific PDGF isoforms, PDGF-? and PDGF-? (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others. Both Tyrosine 751 and 740 is required for PDGFR-? mediated PI3 kinase activation. In particular, Tyrosine 751 is the docking site for P13 kinase (4). |
Cytokine-cytokine receptor interaction Focal Adhesion MAPK signaling pathway |
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis on NIH 3T3 cell lysates using anti-Phospho-PDGF receptor β (pY740), 1:2000 dilution. Cells were either (A) untreated (B) treated with PDGF
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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