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Home Antibody All anti-NTRK1 antibodies

Anti-NTRK1 Antibody EP1056Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301071
  • Rabbit Monoclonal Antibody against NTRK1 (Clone EP1056Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419273) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for NTRK1 (NM_002529)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding tyrosine 680 of human Trk was used as an immunogen. This antibody detects both phosphorylated and unphosphorylated Trk.
Clone NameEP1056Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:20000; IP: 1:20; FC: 1:60
BufferPreservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC or IHC-P.

Reference Data

Target NameHomo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 2
Alternative NameMTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA
Database LinkNP_002520
FunctionThe trk proto-oncogene encodes a 140-kilodalton, membrane-spanning protein Trk that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments indicate that Trk binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Nerve growth factor and its high-affinity receptor Trk are thought to be involved in the progression of various cancers (2). NGF interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and Trk. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving Trk and the low-affinity NGF receptor (3).
Related Pathway
MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-TrkA antibody [EP1056Y]; Anti-TrkA antibody [EP1056Y] at 1/20000 dilution + Human brain tissue lysate at 10 ug.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 87 kDa.

 

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