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Home Antibody All anti-PDGFRB antibodies

Anti-PDGFRB PHOSPHO Antibody EP2136Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301065
  • Rabbit Monoclonal Antibody against PDGFRB (Clone EP2136Y) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Tyrosine 857 of human PDGF-Receptor ? was used as an immunogen. This antibody detects PDGF-Receptor ? phosphorylated at Tyrosine 857
Clone NameEP2136Y IsotypeTissue culture supernatant
Species ReactivityMouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:1000
BufferDoes not react with Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameMus musculus platelet derived growth factor receptor, beta polypeptide (Pdgfrb), transcript variant 2
Alternative NameAI528809; CD140b; Pdgfr; PDGFR-1
Database LinkNP_032835
FunctionHuman platelet-derived growth factor (PDGF) receptor, is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Phosphorylation of Tyrosine 857 (pY857) in the catalytic loop of the PDGF Receptor beta has been shown to increase kinase activity. Two major isoforms exist, PDGF receptor-? and PDGF receptor-?. PDGF receptor-? can only bind two specific PDGF isoforms, PDGF-? and PDGF-? (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others.
Related Pathway

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WB Image
Western blot - PDGF Receptor beta (phospho Y857) antibody [EP2136Y]; All lanes : Anti-PDGF Receptor beta (phospho Y857) antibody [EP2136Y] at 1/1000 dilution.Lane 1 : NIH3T3 cell lysates (untreated).Lane 2 : NIH3T3 cell lysates treated with PDGF.Lysates/proteins at 10 µg per lane.Secondary.goat anti-rabbit, HRP labeled, at 1/2000 dilution.Predicted band size : 123 kDa.Observed band size : 190 kDa .

 

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