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Home Antibody All anti-TP53 antibodies

Anti-TP53 Antibody EP42Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301062
  • Rabbit Monoclonal Antibody against TP53 (Clone EP42Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400186) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
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Also for TP53 (NM_000546)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding serine 46 of human p53 protein.
Clone NameEP42Y IsotypeTissue culture supernatant
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:2000; IP: 1:40; IHC-P: 1:100 - 1:250; ICC: 1:50
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
Functionp53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers. Due to UV-induced DNA damage, p53 is phosphorylated on eight different serine/threonine locations on the N-terminal. Phospholyation on serine 46 has been implicated as a mediator in apoptosis induced by DNA-damage (4, 5).
Related Pathway
Apoptosis
Cell cycle
Delta-Notch Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway

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WB Image
Western blot - p53 (phospho S46) antibody [EP42Y]; All lanes : Anti-p53 (phospho S46) antibody [EP42Y] at 1/2000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : HepG2 cell lysate treated with etoposide.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/1000 dilution.Predicted band size : 53 kDa.Observed band size : 53 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - p53 (phospho S46) antibody [EP42Y]; Immunohistochemical analysis of human ovarian adenocarcinoma using TA301062 at 1/100 dilution.

 

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