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Home All anti-ITGB1 antibodies

Anti-ITGB1 Phospho Antibody EP974(2)Y

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA301047
  • Rabbit Monoclonal Antibody against ITGB1 (Clone EP974(2)Y) (Phospho-specific)
100ul $325 In Stock
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
30ul
$100
$50*
In Stock
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* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
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Also for ITGB1 (NM_002211)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Tyrosine 783 of human Integrin ?-1 (CD29). This antibody detect Integrin ?-1 phosphorylated at Tyrosine 783.
Clone NameEP974(2)Y IsotypeIgG
Species ReactivityHuman Concentration
Guaranteed Application *WB Suggested DilutionsWB: 1:50,000
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Reference Data

Target NameHomo sapiens integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A
Alternative NameCD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB
Database LinkNP_002202
FunctionIntegrin beta-1 (ITGB1, CD29, VLA-beta) is the beta subunit found in the integrin families, forming a heterodimer integrin receptor through non-covalent bonding with various integrin alpha subunits. Integrin heterodimer containing Integrin beta-1 binds to various cell surface and extracellular proteins (CD49a-f, CD51) to mediate cell to cell and cell to matrix adhesion (1). Integrin beta-1 plays a critical role in the cell adhesion and recognition in embryogenesis, hemostasis, immune response, tissue repair, metastatic diffusion of tumor cells and development (2, 3, 4). Observations argue that tyrosines 783 and 795 within the cytoplasmic tail of integrin subunit beta1A are critical mediators of FAK activation and cell spreading in GD25 cells (5).
Related Pathway
Focal Adhesion
Hemostasis

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WB Image
Western blot analysis on U937 cell lysates using anti-Phospho-Integrin β-1 (CD29) (pY783), 1:100,000 dilution. Cells were either (A) untreated (B) treated with pervanadate.

 

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