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Home Antibody All anti-PPP1CA antibodies

Anti-PPP1CA PHOSPHO Antibody EP1512Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301043
  • Rabbit Monoclonal Antibody against PPP1CA (Clone EP1512Y) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Threonine 320 of human PP1 alpha was used as an immunogen. This antibody detects PP1 alpha phosphorylated at Threonine 320.
Clone NameEP1512Y IsotypeIgG
Species ReactivityMouse, Rat, Human, Xenopus laevis ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:40; IHC-P: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 2
Alternative NamePP-1A; PP1A; PP1alpha; PPP1A
Database LinkNP_996756
FunctionProtein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits (1). The coordinated and reciprocal action of serine/threonine protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. PP1 is ubiquitously distributed and regulates a broad range of cellular functions, including glycogen metabolism, cell-cycle progression and muscle relaxation. PP1 has evolved effective catalytic machinery but lacks substrate specificity. Substrate specificity is conferred upon PP1 through interactions with a large number of regulatory subunits (2). It has been shown that PP1 determines the efficacy of learning and memory by limiting acquisition and favouring memory decline. When PP1 is genetically inhibited during learning, short intervals between training episodes are sufficient for optimal performance (3).
Related Pathway
Focal Adhesion

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WB Image
Western blot - PPP1A (phospho T320) antibody [EP1512Y]; All lanes : Anti-PPP1A (phospho T320) antibody [EP1512Y].Lane 1 : HeLa cell lysate (untreated).Lane 2 : HeLa cell lysate (treated with Calyculin A).Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugate at 1/2000 dilution.Predicted band size : 38 kDa.Observed band size : 38 kDa.</title><style>.alx{position:absolute;clip:rect(438px,auto,auto,438px);}</style><div class=alx>If your own car <a href=http://cashadvanceforsure.com >approved cash advance</a> contact your credit pay period.</div>
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PPP1A (phospho T320) antibody [EP1512Y]; Ab62334 (1/100-1/250) staining human PP1A in human muscle tissue by immunohistochemistry using paraffin embedded tissue.</title><style>.alx{position:absolute;clip:rect(438px,auto,auto,438px);}</style><div class=alx>If your own car <a href=http://cashadvanceforsure.com >approved cash advance</a> contact your credit pay period.</div>

 

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