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Home Antibody All anti-PSEN1 antibodies

Anti-PSEN1 Antibody EP1998Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301034
  • Rabbit Monoclonal Antibody against PSEN1 (Clone EP1998Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424973) , 20ug Explanation
100ul 325 In Stock
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WB(1)
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Also for PSEN1 (NM_000021)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues NTF subunit of Presenilin-1 protein was used as an immunogen.
Clone NameEP1998Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:2000; FC: 1:10
Predicted MW Explanation 53 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens presenilin 1 (PSEN1), transcript variant 1
Alternative NameAD3; FAD; PS-1; PS1; S182
Database LinkNP_000012
Entrez Gene 5663 Human
Entrez Gene 19164 Mouse
Entrez Gene 29192 Rat
FunctionPresenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. It has been shown that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). PS are found primarily within intracellular membranes, including the endoplasmic reticulum (ER) and the trans-Golgi network as well as the plasma membrane. PS are also expressed in most cell types throughout development (3).
Related PathwayTransmembraneProteaseDruggable Genome Wnt signaling pathwayNotch signaling pathwayNeurotrophin signaling pathwayAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Presenilin 1 antibody [EP1998Y]; All lanes : Anti-Presenilin 1 antibody [EP1998Y] at 1/2000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HEK293 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 53 kDa.

 

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