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Anti-PSEN1 Antibody EP1998Y
Also for PSEN1 (NM_000021)
|A synthetic peptide corresponding to residues NTF subunit of Presenilin-1 protein was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500 - 1:2000; FC: 1:10
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens presenilin 1 (PSEN1), transcript variant 1|
|AD3; FAD; PS-1; PS1; S182|
|Presenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. It has been shown that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). PS are found primarily within intracellular membranes, including the endoplasmic reticulum (ER) and the trans-Golgi network as well as the plasma membrane. PS are also expressed in most cell types throughout development (3). |
Delta-Notch Signaling Pathway
Wnt Signaling Pathway
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Western blot - Anti-Presenilin 1 antibody [EP1998Y]; All lanes : Anti-Presenilin 1 antibody [EP1998Y] at 1/2000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HEK293 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 53 kDa.